Napolis astonishing comeback seals win against Milan

first_imgNapoli completed an extraordinary comeback from 2-0 down to beat Milan 3-2 under thirty minutes at the Stadio San Paolo.Jack Bonaventura’s acrobatic half-volley and a Davide Calabria angled drive had put Gennaro Gattuso’s men firmly in control at the Stadio San Paolo.However, as they did last week at Lazio, Carlo Ancelotti’s side fought back for the victory.A Piotr Zielinski’s smartly-taken double restored parity for the Naples side before substitute Mertens then pounced at the back-post to complete an unlikely comeback win for Carlo Ancelotti’s new club.Cristiano Ronaldo, JuventusSerie A Betting: Match-day 3 Stuart Heath – September 14, 2019 Considering there is a number of perfect starts so early in the Serie A season, as well as a few surprisingly not-so perfect ones….It was also a notable night for David Ospina’s first start for the hosts since his summer move from Arsenal.The Naples outfit now sit joint-top of the early Serie A table alongside champions Juventus, having both maintained their perfect starts on Saturday.Napoli pushed Juventus all the way in the title race last season and will be hopeful of going one better this time around.last_img read more

Courage On Display at 2015 Neal Awards

first_img Those courageous enough to take on high-profile stakeholders and overcome odds stood out as leaders across the B2B media industry were recognized for editorial excellence at the ABM/SIIA ceremony at Pier Sixty Friday in New York City. Richard Korman, deputy editor at ENR and ENR RiskReview for Dodge Data and Analytics, was one of the individuals honored as winner of The Timothy White Award for Editorial Integrity. Korman has drawn attention for his brave reporting on the construction industry for three decades, including notable recent projects on same-sex bullying and insurance guarantee fraud. Crain took home the most awards (7), the Grand Neal and individual honors for two of its brand leaders. Automotive News won the Grand Neal for its news coverage of General Motor’s ignition-switch recall, while Glenn Coleman, editor-at-large for Crain’s New York Business, was named the 2015 McAllister Editorial Fellow, and Fawn Lopez, publisher and vice president of Modern Healthcare and Modern Physician, took the Gertrude Crain Award for women’s leadership. NEW YORK—In the age of clickbait, the 61st annual Jesse H. Neal Awards were a reminder that courage is still an integral part of good journalism and successful publishing. Korman’s honor was one of several for Dodge Data and Analytics—the company got five Neals, in addition to The Timothy White Award—but Crain Communications was the big winner of the event. Lopez, a Vietnamese immigrant, moved the crowd with her personal journey from a child in the post-war third-world to her current role as a successful media executive. The resolution and leadership exhibited by her father, a former colonel in the South Vietnamese military who worked two jobs to support a family of nine after immigrating to the U.S., continue to motivate her to this day, she said. “My father had big dreams for his children and grandchildren,” Lopez said. “My success is a result of his love, overwhelming commitment to family and a strong belief that we were destined to do great things in life. Since 1975, my life has been filled with struggles, but also many triumphs.” “I’m an investigator, but no Ida Tarbell or Lincoln Steffens or Woodward and Bernstein,” Korman said in his acceptance speech. “I’m an editorial manager attuned to my company’s business goals. We need brilliant websites and fascinating conferences—we need business models that support the resources for Timothy White-, publically-spirited reporting and writing or we won’t be entitled to the trust of our industries. Unless brands treat journalism as a calling, we can’t call it journalism.” ALM also left with an armful of trophies, winning for Best News Coverage, Best Single Issue, Best Range of Work by a Single Author, and several other categories on its way to six awards.More on this topic Connectiv Unveils Neal Award Winners Overdrive Takes Top Honors at 60th Annual Neal Awards ABM’s Grand Neal Goes to IEEE Spectrum ABM Announces Recipients of Crain, Timothy White, and McAllister Fellowship Awards Farm Journal Media Receives Grand Neal award The 52nd Annual Jesse H. Neal AwardsJust In Shanker Out, Litterick In as CEO of EnsembleIQ Editor & Publisher Magazine Sold to Digital Media Consultant PE Firm Acquires Majority Stake in Industry Dive Meredith Corp. Makes Digital-Side Promotions | People on the Move TIME Names New Sales, Marketing Leads | People on the Move Four More Execs Depart SourceMedia in Latest RestructuringPowered bylast_img read more

How Meredith Plans to Implement Live Video and Virtual Reality

first_img Whether on Facebook, Twitter, or elsewhere, live video is almost certainly the hottest new distribution channel of the summer for publishers. Immersive video experiences provided by virtual reality headsets seem to be gathering steam as well, with The New York Times Magazine, Sports Illustrated, and InStyle, among several others, already getting in on the action. Lee adds that the company is using open APIs at its studios in New York and Des Moines to ensure uniform quality and methodology across brands, further indicating that this is a company-wide strategy. A third studio, in Seattle, is scheduled to begin live video production later this year. The company wouldn’t reveal specifics about upcoming initiatives planned once the new technology has been fully implemented, but Melinda Lee, Meredith’s newly appointed SVP and GM of video, tells Folio: that the jump into the new formats comes as marketers are increasingly seeking those capabilities in publishers. The women’s publishing giant whose massive audience continues to grow — as of yesterday’s statement, the company claims to reach 102 million unduplicated women in the U.S. — announced a commitment to expand its relatively nascent Facebook Live activity into a fully-fledged “video innovation” strategy encompassing live video, virtual reality, and 360º video. “We have developed creative expertise in VR and 360º in-house and are training all of our producers on these new production technologies,” Lee tells Folio:. “We started by experimenting on more affordable cameras, but have recently made the investment in higher-end cameras, too.”center_img While Meredith seems no less bullish on the new video formats, Lee cautions that to fully realize the potential of any new medium, it is first necessary to attain a deep understanding of the technology and the ways in which audiences consume it. Yesterday, Meredith Corp. revealed that it, too, had joined the live video and virtual reality craze that seems to be sweeping the consumer publishing industry.  “In order for content creators to fully utilize all the good things that live video and VR can bring to our audiences, we need to fully dive into engagement metrics and iterate on our ability to tell a good story through these new video production technologies,” Lee tells Folio:. “Video insights are more important than ever and we have made an investment here.”More on this topic The Mistake Brands Can’t Afford to Make with Virtual Reality Magazine Publishers Begin to Embrace Virtual Reality Facebook Pays Publishers Over $50 Million to Start Using Live Video Video Programming, Channing Tatum Star at Hearst’s First-Ever NewFronts Meredith to Partner with “Fixer Upper” Stars on New Lifestyle Mag UBM Takes Several Titles Digital-Only as Strategic Shift ContinuesJust In Four More Execs Depart SourceMedia in Latest Restructuring Shanker Out, Litterick In as CEO of EnsembleIQ The Atlantic Names New Global Marketing Head | People on the Move This Just In: Magazines Are Not TV Networks TIME Names New Sales, Marketing Leads | People on the Move Meredith Corp. Makes Digital-Side Promotions | People on the MovePowered bylast_img read more

Mitsubishi Electric and Here are working on a new V2V system for

first_img Share your voice 2019 Mitsubishi Outlander PHEV review: A plug-in SUV that lacks appeal Mitsubishi More From Roadshow The 2020 Mitsubishi Outlander Sport looks bolder than ever 2019 Honda CR-V review: Still one of the best small SUVs around 2020 Mercedes-AMG GT first drive: A refresh that polishes an already good car Enlarge ImageMitsubishi Electric and Here’s Lane Hazard Warning system can identify road hazards like stalled cars or slick pavement and upload that information to the cloud for other cars. Mitsubishi Electric/HERE Mitsubishi Electric — no, not the car maker, but related — and a Dutch company called Here have been working on a vehicle-to-cloud-to-vehicle information system that would allow a car to report a road hazard and share it with other vehicles. The system is called Lane Hazard Warning, and unlike a lot of V2V systems, this one just completed its second successful real-world test, the two companies announced today.The first real-world test of the Lane Hazard Warning system took place in Tsukuba City, Japan, in winter 2018. The second test took place in Southern California and concluded at the end of April. Pretty cool, but what exactly does the system do?First, Lane Hazard Warning uses a vehicle’s sensors to identify potential road hazards such as wrecked cars, big potholes and slippery surfaces. It then flags those hazards and which lane or lanes they affect and sends that data to the cloud where other vehicles equipped with the system can access it.”When something unusual happens on the road ahead drivers often have very little time to react, and that can put them and their passengers at risk,” Hiroshi Onishi, executive officer and group president of Automotive Equipment at Mitsubishi Electric, said in a statement. “Together with Here Technologies, we’ve developed a new system designed to give drivers a few valuable extra seconds or minutes to prepare for a potential danger on the road ahead, such as by switching lanes or simply driving with greater caution. “The two companies are planning to make the system available to automakers for testing, with the ultimate goal being to license the technology out to companies developing self-driving cars or vehicles with advanced driver assistance features. Tags 0 18 Photos Auto Tech Car Industry Post a commentlast_img read more

China castigates US over warship sailby in Taiwan Strait

first_imgFlags of China and USAChina said Thursday it had lodged a protest with Washington after two US warships sailed through the Taiwan Strait amid rising tensions between the two powers.The US Navy said the USS Preble, a destroyer, and USNS Walter S Diehl, a supply ship, conducted a routine transit “in accordance with international law” on Wednesday.”The ships’ transit through the Taiwan Strait demonstrates the US commitment to a free and open Indo-Pacific,” the navy said.”The US Navy will continue to fly, sail and operate anywhere international law allows.”US warships periodically conduct “freedom of navigation” exercises in the narrow waterway separating the Chinese mainland and Taiwan, triggering angry responses from Beijing every time.Beijing views any ships passing through the strait as essentially breaching its sovereignty, while the US and many other nations view the route as international waters open to all.”We have lodged solemn representations with the US,” Chinese foreign ministry spokesman Lu Kang said at a regular press briefing.The sail-by comes on top of tensions between the United States and China over trade and US efforts to thwart Chinese telecom giant Huawei over security concerns.The transit also comes as the US, Japan, South Korea and Australia kicked off operation “Pacific Vanguard” near Guam, bringing together more than 3,000 sailors from the four countries.Drills will focus on “live fire exercises, defensive counter-air operations, anti-submarine warfare, and replenishment at sea,” the US 7th Fleet said.In April, Beijing said its navy warned off a French warship that had entered the Taiwan Strait and lodged an official complaint with Paris.China sees Taiwan as part of its territory to be reunified, despite the two sides being ruled separately since the end of a civil war on the mainland in 1949.The US diplomatically recognises China over Taiwan, but remains the island’s chief military ally and arms supplier.For the Guam naval drills, Australia has contributed two frigates, Japan two destroyers and South Korea one destroyer. The USS Blue Ridge, the 7th Fleet’s flagship, will lead the operation from the US side.Home to more than 160,000 people, Guam was at the centre of nuclear tensions between Washington and Pyongyang in 2017, with North Korea threatening to hit the US territory with “enveloping fire”.last_img read more

Nelson Mandela New Wax Figure at Madame Tussauds

first_imgMadame Tussauds Washington, D.C. celebrates the life of Nelson Mandela with a wax figure of the social and political icon. To remember his life and recognize the two years since his tragic passing, his wax figure will be placed next to the historic “Free Mandela” Sidewalk Slab located on the George Washington University’s campus, H Street, Between 22nd and 21st Streets NW, on Dec. 4 from noon – 2 p.m. For more information, visit madametussaudsdc.com or call 202-942-7300.last_img

Solo A Star Wars Story Tops Studios TV Ad Spending

first_imgImpressions: 189,069,187Attention Score: 89.27Attention Index: 69National Airings: 501Networks: 31Most Spend On: ABC, NickCreative Versions: 19Est. Lifetime TV Spend: $11.12MStudio: Disney PixarStarted Airing: 11/18/17 1 Movie titles with a minimum spend of $100,000 for airings detected between 05/14/2018 and 05/20/2018.* TV Impressions – Total TV ad impressions delivered for the brand or spot.* Attention Score – Measures the propensity of consumers to interrupt an ad play on TV. The higher the score, the more complete views. Actions that interrupt an ad play include changing the channel, pulling up the guide, fast-forwarding or turning off the TV.* Attention Index – Represents the Attention of a specific creative or program placement vs the average. The average is represented by a score of 100, and the total index range is from 0 through 200. For example, an attention index of 125 means that there are 25% fewer interrupted ad plays compared to the average.Variety has partnered with iSpot.tv, the real-time TV ad measurement company with attention analytics from more than eight million smart TVs, to bring you this weekly look at what studios are spending to market their movies on TV. Learn more about the iSpot.tv platform and methodology. Top Movie Commercials by Weekly TV SpendData provided by iSpot.tv Impressions: 323,651,845Attention Score: 92.45Attention Index: 98National Airings: 1,307Networks: 37Most Spend On: ABC, NBCCreative Versions: 41Est. Lifetime TV Spend: $20.09MStudio: Twentieth Century FoxStarted Airing: 04/16/18 TV ad placements for Twentieth Century Fox’s “Deadpool 2” (EMV: $3.75 million), Warner Bros.’ “Ocean’s 8” ($3.69 million) and Disney Pixar’s “Incredibles 2” ($3.39 million) round out the chart. Notably, “Show Dogs” has the best iSpot Attention Index (122) in the ranking, getting 22% fewer interruptions than the average movie ad (interruptions include changing the channel, pulling up the guide, fast-forwarding or turning off the TV). Popular on Variety $5.31M – Solo: A Star Wars Story $3.75M – Deadpool 2 $3.69M – Ocean’s 8center_img $3.88M – Show Dogs Impressions: 283,169,910Attention Score: 94.21Attention Index: 122National Airings: 1,205Networks: 29Most Spend On: Nick, UnivisionCreative Versions: 20Est. Lifetime TV Spend: $11.35MStudio: Global RoadStarted Airing: 03/24/18 Impressions: 200,172,176Attention Score: 94.19Attention Index: 121National Airings: 344Networks: 47Most Spend On: ABC, TNTCreative Versions: 5Est. Lifetime TV Spend: $6.77MStudio: Warner Bros.Started Airing: 05/07/18 In this week’s edition of the Variety Movie Commercial Tracker, powered by the TV advertising attention analytics company iSpot.tv, Lucasfilm claims the top spot in spending with “Solo: A Star Wars Story.”Ads placed for the “Star Wars” franchise prequel had an estimated media value of $5.31 million through Sunday for 784 national ad airings on 37 networks. (Spend figures are based on estimates generated from May 14-20. Estimates may be updated after the chart is posted as new information becomes available.) Lucasfilm prioritized spend across networks including ABC, NBC and ESPN, and during programming such as NBA Basketball, Designated Survivor and American Idol. Just behind “Solo: A Star Wars Story” in second place: Global Road’s “Show Dogs,” which saw 1,205 national ad airings across 29 networks, with an estimated media value of $3.88 million. $3.39M – Incredibles 2 Impressions: 317,580,825Attention Score: 92.39Attention Index: 97National Airings: 784Networks: 37Most Spend On: ABC, NBCCreative Versions: 39Est. Lifetime TV Spend: $17.02MStudio: LucasfilmStarted Airing: 04/08/18 ×Actors Reveal Their Favorite Disney PrincessesSeveral actors, like Daisy Ridley, Awkwafina, Jeff Goldblum and Gina Rodriguez, reveal their favorite Disney princesses. Rapunzel, Mulan, Ariel,Tiana, Sleeping Beauty and Jasmine all got some love from the Disney stars.More VideosVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9Next UpJennifer Lopez Shares How She Became a Mogul04:350.5x1x1.25×1.5x2xLive00:0002:1502:15last_img read more

Physicists demonstrate new violations of local realism

first_img Journal information: Scientific Reports When two objects are entangled, a measurement on one object instantly affects the state of the other, even more quickly than light could travel between them. This instantaneous action goes against our intuition that an object should be affected only by its immediate surroundings, a concept known as locality.For years, physicists struggled to definitively answer the question of whether or not entangled states truly violate local realism—that is, do they violate either locality or realism, where realism is simply the assumption that objects exist even when they’re not being observed? Although it was long suspected that at least some entangled states violate local realism due to how they seem to instantly influence each other, it wasn’t until 1991 that physicist Nicolas Gisin at the University of Geneva quantitatively demonstrated that all pure entangled states must violate local realism. This result is now known as Gisin’s theorem.In quantum mechanics, a “pure” entangled state is one that is clearly defined. However, the vast majority of entangled states are “mixed” to some degree, meaning they consist of a combination of multiple types of pure states. Although Gisin’s theorem holds only for pure states, over the years physicists have extended the theorem by showing that some other types of states can also violate local realism. In a new paper to be published in Nature Scientific Reports, Jing-Ling Chen, et al., from institutions in China and Singapore, have demonstrated that all mixed states that obey a certain steering property must violate local realism. This new family of entangled mixed states that violate local realism may lead to a better fundamental understanding of quantum correlations, as well as simplify the implementation of some quantum information protocols.”Our enhanced Gisin’s theorem is the first time that the theorem has been generalized from pure states to mixed ones, and includes the original Gisin’s theorem as a special case,” Chen, a physicist at Nankai University in China and the National University of Singapore, told Phys.org. Quantum test strengthens support for EPR steering More information: Jing-Ling Chen, et al. “Beyond Gisin’s Theorem and its Applications: Violation of Local Realism by Two-Party Einstein-Podolsky-Rosen Steering.” Sci. Rep. 5, 11624; DOI: 10.1038/srep11624. To be published. Also at arXiv:1404.2675 [quant-ph] Citation: Physicists demonstrate new violations of local realism (2015, June 10) retrieved 18 August 2019 from https://phys.org/news/2015-06-physicists-violations-local-realism.html By extending Gisin’s theorem from pure states to mixed states that obey a certain property, the results of the new paper could have applications for quantum certificate authorization protocols, like the one shown here. Credit: Chen, et al. ©2015 Nature Scientific Reports Explore further Two distinct conceptsChen explained the problem in more detail:”It has long been well-known, starting from Werner’s seminal 1989 paper ‘Quantum states with Einstein-Podolsky-Rosen correlations admitting a hidden-variable model,’ that entanglement and violation of local realism are two distinct concepts. Some entangled quantum states admit a local hidden variable model and hence do not violate local realism. An important question arises. Can we pinpoint a condition that constrains quantum states to those for which entanglement is equivalent to a violation of local realism? A possible condition is purity. Any pure entangled quantum state violates Bell’s inequalities. This is known as Gisin’s theorem. “For a more general case of mixed states, however, researchers have been concerned about a lack of such a condition. The more general condition is of great significance not only from the theoretical viewpoint of the need for a deeper understanding of quantum correlations. It is also important in experiments, and for quantum informational applications. Since a quantum system inevitably interacts with its environment, the quantum states practically always are to some degree ‘mixed.’ In this work, we address this problem and propose to use the concept of Einstein-Podolsky-Rosen steering as a condition to bridge entanglement and violations of local realism.” Three forms of correlationsAs Chen explained, entanglement, steering, and violations of local realism can be thought of as three different forms of quantum correlations that form a hierarchical structure, with violations of local realism being the strongest form. Steering, the intermediate form, takes the correlations of entanglement a step further so that one system can control—or “steer”—the state of its entangled partner. Here, the physicists demonstrated that, if two observers are able to steer each other’s qubits into pure states by making a measurement on their own qubit that spontaneously collapses the state of the other’s qubit, then even if the qubits were originally in mixed states, they must violate local realism. “This proposed condition is more intrinsic, in the sense that Einstein-Podolsky-Rosen steering is by definition a form of quantum correlation that is intermediate between just entanglement and a much stronger one: violation of local realism,” Chen explained. “Our result provides an important step forward to solving a long-standing problem of pinpointing a physical condition that automatically implies violation of local realism by an entangled state.”Overall, the findings help establish rigorous criteria for marking the borders between these three highly related yet different concepts.”In this hierarchical structure of entanglement, steering, and violations of local realism, the former contain the latter as a subset,” Chen explained. “[Marking the borders between them] is a nontrivial problem since, in general, it is not easy to reduce a superset [entanglement] to a subset [violations of local realism] by imposing extra constraints, which is just EPR steering in our work.”As the scientists explain, the new family of states that violate local realism could provide a new resource for quantum information tasks by reducing the number of entangled particles needed to perform a task. One example is the Third Man cryptography protocol, also called “secret sharing,” in which a third party can control whether two people are allowed to secretly communicate with each other. Previous versions of this protocol required three entangled qubits, but because the fidelity of three-particle entangled states is currently still below about 90%, it is very error-prone. Using the new states, the protocol can be implemented with just two entangled qubits, which has a fidelity of more than 99% and therefore a much lower error rate.Another potential application is quantum certificate authorization, in which a person sending a confidential message through the internet to another person can ask a third party to verify that person’s identity. One way that the third party might do this is by ensuring that both the sender and the receiver can steer each other’s qubits into pure states. If they can, the entangled states must violate local realism, which ensures a secure protocol. The physicists plan to use the new family of EPR-steerable mixed states to experimentally realize these protocols in the near future. (Phys.org)—Erwin Schrödinger once famously stated that quantum entanglement is “the characteristic trait of quantum mechanics” that distinguishes it from classical theories. Now in a new paper, physicists have demonstrated a new family of entangled states that violates the principle of “local realism”—an intuitive concept that is a standard feature of classical theories, but disturbingly at odds with quantum theory. © 2015 Phys.org This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Shuddle the Ridesharing Service for Kiddos and Grandparents Raises 10 Million

first_img Listen Now Problem Solvers with Jason Feifer 2 min read Soccer practice for one kiddo. Band practice for the other. The dentist for you. The physician for your mom, who can’t drive herself.Wednesdays can feel like a finely tuned game of Jenga — which is exactly the appeal of family-focused ridesharing startup Shuddle. The San Francisco-based company, specifically designed to chauffeur children, announced today that it has raised $9.6 million in its Series A round. In total, Shuddle has raised $12 million so far.Related: Busy Parents: Meet Shuddle, the Uber for Kids“Nearly every parent struggles with getting their kid(s) from point A to point B because they often need to be in two places at once. Shuddle solves this problem,” said Steve Schlafman, Principal at RRE Ventures, the VC house that led the deal, in the statement announcing the funding raise.That may be true. But hoisting your children and grandparents into the car of a stranger is a tall ask with a lot of potential pitfalls.To address concerns, Shuddle has specifically tailored insurance for its drivers to be able to carry minors. Also, drivers have to pass a stringent verification and screening process.The startup launched in San Francisco and is currently operating within the Bay area and has 200 female drivers as part of its network. Shuddle CEO Nick Allen was a co-founder of the Uber and Lyft ridesharing competitor Sidecar.Related: Secrets to Being Both an Executive and a Momcenter_img Hear from business owners and CEOs who went through a crippling business problem and came out the other side bigger and stronger. March 18, 2015last_img read more

Blender 28 beta released with a revamped user interface and a highend

first_imgThe Blender team released beta version 2.8 of its Blender, a free and open-source 3D creation software, earlier this week. Blender 2.8 beta comes with new features and updates such as EEVEE, a high-end Viewport, Collections, Cycles, and 2D animation among others. Blender is a 3D creation suite that offers the entirety of the 3D pipeline including modeling, rigging, animation, simulation, rendering, compositing, and motion tracking. It allows video editing as well as game creation. What’s new in Blender 2.8 Beta? EEVEE Blender 2.8 beta comes with EEVEE, a new physically based real-time renderer. EEVEE works as a renderer for final frames, and also as the engine driving Blender’s real-time viewport. It consists of advanced features like volumetrics, screen-space reflections and refractions, subsurface scattering, soft and contact shadows, depth of field, camera motion blur and bloom. A new 3D Viewport There’s a new and modern 3D viewport that was completely rewritten. It can help optimize the modern graphics cards as well as add powerful new features. It consists of a workbench engine that helps visualize your scene in flexible ways. EEVEE also helps power the viewport to enable interactive modeling and painting with PBR materials. 2D Animation There are a new and improved 2D drawing capabilities, which include a new Grease Pencil. Grease Pencil is a powerful and new 2D animation system that was added, with a native 2D grease pencil object type, modifier, and shader effects. In a nutshell, it helps to create a user-friendly interface for the 2D artist. Collections Blender 2.8 beta introduces ‘collections’, a new concept that lets you organize your scene with the help of Collections and View Layers. Cycles Blender 2.8 beta comes with a new feature called Cycles that includes new principled volume and hair shaders, bevel and ambient occlusion shaders, along with many other improvements and optimizations. Other features Dependency Graph: In blender 2.8 beta, the core object evaluation and computation system have been rewritten. Blender offers better performance for modern many-core CPUs as well as for new features in the future releases. Multi-object editing: Blender 2.8 beta comes with multiple-object editing that allows you to enter edit modes for multiple objects together. For more information, check out the official Blender 2.8 beta release notes. Read Next Mozilla partners with Khronos Group to bring glTF format to Blender Building VR objects in React V2 2.0: Getting started with polygons in Blender Blender 2.5: Detailed Render of the Earth from Spacelast_img read more

Singapore Airlines to place US138B order for Boeing aircraft

first_imgSingapore Airlines to place US$13.8B order for Boeing aircraftSingapore Airlines (SIA) has agreed to place firm orders with Boeing for 20 777-9s and 19 787-10s, for additional growth and fleet modernisation through the next decade. SIA has today signed a letter of intent with the US airframe manufacturer comprising the 39 firm orders plus six options for each aircraft type, which if exercised will enlarge the deal to as many as 51 aircraft. The 777-9s are due for delivery from the 2021/22 financial year and the 787-10s for delivery from the 2020/21 financial year. The proposed order, which is valued at US$13.8 billion based on published list prices, includes flexibility for the SIA Group to substitute the 787-10 orders for other variants of the 787 family. “Today’s major order for widebody aircraft enables us to continue operating a modern and fuel-efficient fleet, providing the SIA Group with additional expansion opportunities to ensure that we retain our industry-leading position,” said SIA CEO, Mr Goh Choon Phong. “We are continuing to invest for the future of the SIA Group. This order is also another demonstration of our commitment to further growing the Singapore hub, as we will be able to offer even more travel options for our customers.” The General Electric GE9X is the sole engine type for the 777-9s, which are intended primarily for use on long-haul routes. SIA has selected the Rolls-Royce Trent 1000 to power the 787-10s, which are to be operated on medium-range routes.SIA is a longstanding Boeing customer with more than 50 current-generation 777 aircraft in service. Subsidiaries SilkAir, Scoot and SIA Cargo are also operators of Boeing aircraft, with 737-800s, 787-8/9s and 747-400 Freighters in service, respectively. This is the SIA Group’s first order for the newest 777 variant that is currently under development, the 777-9. SIA is already the launch customer for the 787-10, which is also currently in development, having placed an initial order in 2013 for 30 aircraft for delivery from the 2018/19 financial year. In addition to the 30 previously-ordered 787-10s, SIA has outstanding orders with Airbus for five A380-800s and 57 A350-900s. SilkAir has outstanding orders with Boeing for 37 737 MAX 8s, while Scoot has orders with Boeing for eight 787-8/9s and Tigerair has orders with Airbus for 39 A320neos.Source = Singapore Airlineslast_img read more

Making money is first and foremost about backing t

first_imgMaking money is first and foremost about backing the right people.Next, it’s about timing.Casey Research readers have had great success by identifying, following, and backing up-and-coming stars. The best of the best in the business.          In this video, Louis James from Casey Research introduces you to two innovators of tomorrow.These are two people whom smart investors are following very closely.last_img

first_img— — • These stocks soared because Trump made it his mission to revive the U.S. coal industry… Trump did this for a couple of reasons. Number one, he wants to bring back coal mining jobs. He also believes that a strong domestic coal industry “protects our national security, public safety, and economy from intentional attacks and natural disasters.”But don’t worry if you missed out on this big move in coal stocks.That’s because Trump could soon spark another big rally in energy stocks… and this one could blow the move we saw in coal stocks out of the water.I’ll show you how to position yourself for this in a minute. But first, let me tell you what Trump’s up to…• On June 1, Trump issued a controversial directive…He told Energy Secretary Rick Perry to take “immediate steps” to ensure that coal-fired and nuclear power plants stay open.I say “controversial” because many people don’t think Trump should be supporting coal over cleaner energy sources. Other critics warned that the move could raise energy prices.Still, I expect Trump to follow through on this.That’s because the White House has already instructed the Department of Energy (DOE) to place a two-year moratorium on nuclear power plant closures. The Trump administration is also considering a plan that would direct regional transmission companies to buy power from coal and nuclear plants.Trump’s calling for these measures because he wants to ensure a reliable energy source and to “promote the national defense and maximize domestic energy supplies.”If this goes through, it would be an unprecedented intervention by the federal government into the domestic energy market. It would also likely have massive implications for one commodity. And no, not coal. Recommended Link Recommended Link Why the Next Mega Bull Market Is NOT in StocksDr. Steve Sjuggerud says that another, hidden Melt Up is just beginning. Prices are as cheap today as they were in 1991. Full details here… Trump Declares National Emergency President Trump has mobilized his entire Administration to battle this problem by declaring it a National Emergency under federal law. And Congress just approved $6 billion to fight it. Now a company is joining the battle by tackling one of the biggest problems our country has ever faced. In the past, companies in this niche saw peak gains of 95,800%, 63,400%, even 216,100%. Could this new company be the next to ride this unique wave? Get all the details here before it’s too late. • I’m talking about uranium… The primary fuel used in nuclear power plants.It’s also one of the world’s most dependable energy sources. Unlike many renewable energies, it’s a form of base power. It provides power around the clock. It doesn’t matter if the wind’s blowing or if the sun’s shining.Uranium is also one of the world’s cheapest sources of energy.• Because of these advantages, uranium accounts for about 20% of America’s power needs… But get this… The United States only produces about 7% of the uranium it uses.The rest comes from abroad. And about one-third comes from Russia, Kazakhstan, and Uzbekistan, which is problematic for obvious reasons.In short, America’s uranium supply is incredibly fragile. This is why Trump’s putting U.S. nuclear energy “first.”In his eyes, it’s a matter of economic and national security. And I expect Trump to do a lot more for the nuclear energy industry in the coming years.• Energy Fuels and Ur-Energy are calling for major reforms to America’s uranium industry… Energy Fuels and Ur-Energy are two of America’s biggest uranium producers.Recently, they asked the U.S. Commerce Department to radically rethink its uranium policies. Specifically, they requested that 25% of all U.S. uranium be purchased from U.S. producers for national security reasons. That’s about three times more uranium than U.S. producers currently provide. They also think that U.S. agencies should be required to buy all uranium from domestic sources. • Now, companies lobby for changes like this all the time… Often their requests fall on deaf ears.But I think Trump will take this request seriously. After all, he’s already shown a serious commitment to reviving the country’s nuclear power.And here’s the thing…• Trump won’t have to do much for uranium to skyrocket… Again, that’s because uranium is already dirt cheap.It’s down 83% since 2007. And it’s down about 34% over the past three years. That makes it the worst-performing major commodity, according to Palisade Research.More importantly, the uranium price is now below the industry-wide cost of production. This means the typical uranium producer is losing money.This isn’t sustainable. Sooner or later, the price of uranium will rise. And when it does, watch out. We could have a “rip your face off” rally on our hands.But don’t just take my word it…• Doug Casey’s extremely bullish on uranium, too… A few days ago, Doug said in an interview that “uranium may be my single favorite commodity.”Doug also said that now’s a better time to buy uranium than it was before the last major bull market.Keep in mind, the price of uranium soared from $10 to $140 during the last bull market. The best uranium stocks went 20-to-1 or 50-to-1. Some even went 100-to-1.So, consider speculating on uranium stocks if you haven’t yet.The safest way to do this is with the Global X Uranium ETF (URA). It allows you to bet on a basket of uranium stocks, which is less risky than buying individual stocks.Just understand that uranium stocks are extremely volatile.Blue-chip uranium stocks can swing 5% or more in day. Junior uranium stocks can move 20% or more.If you can’t handle that volatility, you should stay on the sidelines. And if you’re willing to speculate, don’t bet more money than you can afford to lose. Use stop losses. And take profits when you get them.Regards, Justin Spittler Lima, Peru June 20, 2018P.S. Crisis Investing editor Nick Giambruno is also bullish on uranium. He’s dedicated a section of his portfolio to the best uranium plays he’s found. And all are still buys today. You can access these names—and all of Nick’s research on the sector—with a subscription to Crisis Investing. Reader MailbagAre you planning on investing in uranium? Let us know your thoughts on this idea—and any questions or suggestions you have for the Dispatch—right here. By Justin Spittler, editor, Casey Daily Dispatch“America First.”Donald Trump has been pledging this since the campaign trail. And unlike some of his promises, Trump’s stayed true to these words.He’s already put America first when it comes to trade, national security, immigration, and most recently outer space.Now, you might not agree with these policies. But the Dispatch isn’t about politics. It’s about making money.And you can’t deny that Trump’s “America First” approach has helped spark some huge market moves.Just look at this chart. It shows the performance of the VanEck Vectors Coal ETF (KOL) compared to the S&P 500 since Trump’s inauguration.You can see that KOL rose up to 49% at its peak after Trump’s inauguration… compared to a 27% peak gain for the S&P 500.last_img read more

At my babys sixmonth appointment a few months ba

first_imgAt my baby’s six-month appointment a few months back, I got a one-pager from the pediatrician titled “Starting Solid Foods.””It is critical that the baby develop a taste for rice cereal at the beginning, to offset the loss of iron from formula or breast milk,” it reads.Sounds serious. Then come the all caps: “THE FIRST TWO WEEKS OF FEEDING GIVE RICE CEREAL ONLY.” That is followed by advice to introduce pureed vegetables before fruits so the baby doesn’t develop a sweet tooth.I obediently went out and bought some sand-textured baby cereal. (Organic, of course.)”Oh no, we’re not doing that.” My spouse pointed me to a parenting book we had on the shelf. “There’s no need for cereals alone; they are bland and bulky and their iron benefits are overstated,” it reads. “The idea that you should introduce vegetables before fruits to avoid creating a sweet tooth is just an unfounded myth. A carrot has virtually the same amount of sugar as an apple.”Welcome to early parenthood’s barrage of contradictory advice. It tends to be detailed, with convincing internal logic. “Studies” are often invoked. And the stakes feel so high — like, if I do this wrong, will my baby be malnourished or end up a picky eater or not succeed in life somehow?Enter Brown University economics professor Emily Oster and her new book, Cribsheet: A Data-Driven Guide to Better, More Relaxed Parenting, From Birth to Preschool. It’s the follow-up to her first book, Expecting Better, a deep look at the data behind pregnancy advice, which has a bit of a cult following. (I am in this cult.)In her new book, Oster ticks through big and small parenting dilemmas. She uses her training as an economist to look at the relevant research for each of them and to assess how much stock we should put in the findings.”What I do in the book is actually try to comb through these studies and figure out which of them are giving us the best information,” Oster says. “So then you can make these choices having the best information, not just the first thing that comes up when you Google it at 3 o’clock in the morning.”OK, so what about my solid-food dilemma? Yea or nay on rice cereal? Veggies first?”It turns out there isn’t any evidence to suggest that is a particularly important way to introduce foods or not,” she says. The answer to this one: You do you. Keep the food mushy, and don’t stress about it too much.This wasn’t my only point of confusion that this book cleared up, even though I’m nearly four years into parenthood. Here are a few of my personal takeaways.Nipple confusion is not a thing — you don’t need to wait three weeks after birth to give a pacifier or bottle. (This makes me feel better about giving my firstborn a pacifier on day two.)Baby milestones have a wide normal range, so don’t obsess. (Still vaguely worried that by nine months my baby should be clapping.)Breastfeeding does not help mom lose weight. (Crushed.)A lot of the other takeaways are kind of nuanced. They don’t give you a clear-cut answer, so much as information to help you make your own decision. One reason for that is designing a good study of the risks and benefits of a parenting decision is really hard. Take, for example, Chapter 4: “Breast Is Best? Breast Is Better? Breast Is About the Same?” Oster provides a path through the maze of conflicting advice by sifting out the convincing studies from the questionable ones.”Most of the studies on this are done by comparing the kids whose moms breastfeed to the kids whose moms don’t,” Oster says. “The issue with that is that the kind of moms who breastfeed are different than the moms who don’t, on average. So, in the U.S. in particular, moms who breastfeed tend to be better educated, higher income, more likely to be married.”(It’s unclear why that demographic breastfeeds more, Oster says, but the timing for the trend is connected to the public health push away from formula that began in the 1970s.) Now, let’s say you want to find out the impact of breastfeeding — and not of these demographic differences — on things like IQ and obesity.”When we narrow in on some studies that are better — like, for example, studies that compare siblings, where one sibling is breastfed and one sibling is not — those studies do not show the same kinds of impacts on long-term things like obesity or IQ,” Oster says.For the record, she found that there are some health benefits to breastfeeding, but they’re more limited than the hype. If it works for you and your family, Oster concludes, great; if not, formula is a good option.So, even if you’ve made a decision about how to introduce solids and whether to breastfeed or bottle-feed, there are so many other ones to make! What about baby nap schedules, how to potty train or the financial impact of choosing a nanny versus day care versus staying at home?As an economist, Oster advocates for taking some of the angst out of it. When making a parenting decision, she says, “Step one is to kind of really figure out what the best evidence says about the choice.” Look for randomized studies and big sample sizes.”But then there’s a really important second step, which is to combine that with what is going to work for your family,” she says.For instance, when she first brought her baby daughter home, she knew the American Academy of Pediatrics recommends that your baby sleep in your room, ideally for the whole first year, as part of its safe infant sleeping environment guidance.”My husband did one day with our older daughter, and he was like, ‘I can’t believe it’s making those noises.’ He just couldn’t do it. He wouldn’t sleep,” she says. Room sharing for a full year was just not workable for her family.With Cribsheet, Oster is trying to make parents less confused, more confident in their choices and less judgmental of other parents who make different choices. Reading the book makes that feel surprisingly achievable. Laying out the research really strips these decisions of their drama, and you end up wondering why it all felt so overwhelming in the first place.When the time came to break out the solid foods with my baby, we did mashed sweet potato. A few months into it, emboldened by Oster’s book, we’ve gotten adventurous: This weekend at our Seder, baby even had a bit of brisket smushed up with horseradish. Copyright 2019 NPR. To see more, visit https://www.npr.org.last_img read more

Snapchat Introduces a Group Video Call Feature

first_img April 6, 2018 1 min read Next Article Plus, 82Labs raises $8 million, and a self-care startup raises $5 million. –shares Opinions expressed by Entrepreneur contributors are their own. Snapchat introduced a new video group chat feature. This new addition will let you chat with 16 of your closest friends and do a voice call with up to 32 people. Getting started is simple. You tap the video icon in the group chat or start a call with a few people and then invite new friends to join.The hangover recovery drink from 82Labs has raised $8 million. This special morning-after recovery drink has vitamins, electrolytes and an herbal medicine called DHM that apparently makes your hangover magically go away. The new funding is from Altos Ventures, Slow Ventures, Strong Ventures and Thunder Road Capital.A self-care startup called Shine raised $5 million in series A funding. Shine is a free service that sends you a daily text to help you thrive. It sends quotes, research-backed articles and actionable advice to help you start your morning off right. Shine has 2 million active users to date. The only list that measures privately-held company performance across multiple dimensions—not just revenue. Apply Now »center_img News and Trends Snapchat Introduces a Group Video Call Feature VIP Contributor Add to Queue 2019 Entrepreneur 360 List Venturer Snap Introduces A Group Video Call FeaturePlus, 82Labs raises $8 million dollars, and a self-care startup raises $5million dollars!last_img read more

Twitter Retweets Can Now Contain Photos Videos GIFs

first_img Image credit: via PC Mag Twitter Retweets Can Now Contain Photos, Videos, GIFs New Twitter features roll out at a snail’s pace, with the memorable big changes being the increase in character limit and the switch from stars to hearts. This week we got a smaller, but still significant change to retweets. It’s now possible to retweet with a photo, video, or GIF attached.As The Verge reports, retweeting until now has been limited to two options: a simple retweet of the original tweet, or you could retweet with a comment. It’s that second option which is being expanded to allow the inclusion of media. So clicking “Retweet with comment” will now allow you to embed a photo, a video, or a GIF.For now, the retweet tweak is limited to Twitter on Android, iOS, or the Twitter mobile website. Desktop users don’t have access to it yet and these new media-rich retweets will look a little strange on desktop until that’s fixed. Even so, it’s sure to be a welcome update by users who’d rather not be limited to text when sharing someone else’s tweet with their followers.From Twitter’s point of view, the change proved quite challenging because it was difficult to get the layout right without things looking confusing. Stacking media can make the stream of information look muddled, so Twitter needed it to be very clear how the media was linked between the two tweets. This was achieved by placing the original tweet in a smaller box below the retweet, but also indented from it. That way the retweet looks more prominent, but it’s visually quite clear it’s a response to the indented tweet below.Retweeting with media is already being used and some major brands are taking full advantage, including Game of Thrones. It’s one of those features that will soon become a natural part of retweets and we’ll all forget how limited retweeting used to be. 2019 Entrepreneur 360 List Add to Queue The only list that measures privately-held company performance across multiple dimensions—not just revenue. This story originally appeared on PCMag Senior Editor Next Article center_img It’s a relatively small change for users, but apparently a really challenging new feature for Twitter to implement and get right. May 7, 2019 Twitter 2 min read Apply Now » Matthew Humphries –shareslast_img read more

Dealing With Internal Security Threats

first_img May 6, 2003 –shares Technology Next Article Add to Queue 4 min readcenter_img Opinions expressed by Entrepreneur contributors are their own. It’s often the internal, not external, threats that pose the greatest risk to your network. Are you prepared for the worst? Dealing With Internal Security Threats Q: How easily could a nontechnical internal employee hack my company’s network?A: With all the recent press regarding the sharp rise in Internet-based external threats, is it any wonder that internal threats continue to be overlooked? Many companies today continue to focus the majority of their budgets and effort on “external” penetration and denial of service (DOS) risks. Regardless of the source, you will consistently find that internal security breaches continue to lead to external breaches by a significant majority. In fact, the risk of internal attacks is very likely to rise in the coming year due to the growth, sophistication and ease of use of hacking tools available online.For years, security professionals have commonly communicated the vulnerabilities of operating systems and network services–such as Web, e-mail, ftp and telnet–to the public in many forms. In order for would-be hackers or disgruntled employees to take advantage of these published vulnerabilities, they’d have to create application code or scripts after studying the notes of a select group of experts who originally discovered and documented the vulnerability. Taking advantage of these security holes would require a level of knowledge beyond that of many common IT administrators and the majority of nontechnical individuals. Hence, the most common threats from nontechnical internal employees have mostly been limited to a matter of improperly managed permissions, weak authentication and other administrative-level issues.Over the past year, the number of precoded exploit applications has been on the rise. The more sophisticated hackers are now writing and publishing applications that nontechnical individuals can use on UNIX or Windows PCs. These exploit applications can scan internal networks for vulnerable servers and then perform a specific exploit against the selected target.The most common type of attack used by these new applications is DOS attacks that crash production servers with little or no way to track the source of the problem. Crashing a server is a significant issue since it not only affects productivity, but can also corrupt data, causing integrity issues. The need is apparent for constant attention to security patches and fixes as well as internal auditing and/or intrusion detection systems.Internal auditing is one critical aspect of a security plan that can reduce the risk associated with these new attack tools. However, many internal-auditing projects, if they are being done at all, focus on high-level policy issues like weak passwords, directory and file permissions, and disaster-recovery procedures. Often, it is only the external audits that commonly test for the actual operating system and network service vulnerabilities being exploited by this new age of hacking tools. It is vital that the IT managers evaluating security-auditing vendors be sure that internal-auditing vendors provide a comprehensive analysis of the operating system and application vulnerabilities. Without this analysis, these new risks to business continuance and data integrity may go undetected until they directly affect the bottom line.Many managers assume that nontechnical employees do not pose a significant risk to business continuance from an information security standpoint. Unfortunately, because of the easy access to more sophisticated exploit tools, that assumption is costing business today in terms of service outages and lost revenue. Know your risks and remediation requirements by performing an internal audit before your company becomes the next victim.Michael Bruck is the founding partner of BAI Security, an 8-year-old information security consulting firm. Bruck leads his security team with a successful 16-year background in IT management and senior engineering positions. He is also the developer and author of best practices that are becoming standards in the information security consulting business. He can be reached via www.baisecurity.netor by e-mail at mbruck@baisecurity.net.The opinions expressed in this column are those of the author, not of Entrepreneur.com. All answers are intended to be general in nature, without regard to specific geographical areas or circumstances, and should only be relied upon after consulting an appropriate expert, such as an attorney or accountant.last_img read more

Hillary Clinton on Why Failure Should Not Hold You Back

first_img Entrepreneur Staff Hillary Clinton on Why Failure Should Not Hold You Back 2 min read November 9, 2016 Nina Zipkin Add to Queue Image credit: Getty Images | Justin Sullivan Next Article Goalscenter_img Staff Writer. Covers leadership, media, technology and culture. Free Webinar | July 31: Secrets to Running a Successful Family Business –shares The Democratic candidate provided valuable advice in her concession speech. In a graceful concession speech in New York City on Wednesday, Hillary Rodham Clinton brought her historic campaign to a close with some valuable advice about how to contend with failures and setbacks in the course of your career.After thanking her family, her running mate Sen. Tim Kaine, President Barack Obama and First Lady Michelle Obama, her campaign staff and volunteers across the country, Clinton reflected on what she had learned in her decades of service.Related: 5 Ways to Get Going Again After You’ve Survived a Setback”I’ve had successes and setbacks and sometimes painful ones,” she said. “Many of you are at the beginning of your professional, public and political careers. You will have successes and setbacks too. This loss hurts, but please never stop believing that fighting for what’s right is worth it.”Clinton also encouraged unity.Related: Why True Entrepreneurs View Setbacks As Opportunities”I still believe in America, and I always will. And if you do, then we must accept this result and then look to the future,” she said. “Donald Trump is going to be our president. We owe him an open mind and the chance to lead. Our constitutional democracy enshrines the peaceful transfer of power.”She wrapped up her speech emphasizing the importance of continuing to work hard, pursue every dream and opportunity and have the strength and courage of your convictions.No matter where you fall on the political spectrum, that’s advice we can all take to heart. Learn how to successfully navigate family business dynamics and build businesses that excel. Register Now »last_img read more

Potential treatment for rare poliolike illness shows no signal of efficacy

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Nov 9 2018Researchers have been searching for possible treatments for the polio-like illness causing paralysis in children, called acute flaccid myelitis. But a new study shows no signal of efficacy for one potential treatment, the antidepressant fluoxetine. The study is published in the November 9, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.Research suggests that the virus called enterovirus D68, or EV-D68, is one possible cause of acute flaccid myelitis. Lab tests showed that fluoxetine had antiviral effects against EV-D68, so the antidepressant was suggested by various experts as a possible treatment for acute flaccid myelitis, which can cause sudden muscle weakness in the arms, legs or neck, drooping eyelids and difficulty swallowing, speaking and breathing.”The lack of an efficacy signal for the treatments for acute flaccid myelitis evaluated in this study emphasizes the need for development and prospective evaluation of more effective treatment and prevention strategies for this potentially devastating condition,” said study author Kevin Messacar, MD, of Children’s Hospital Colorado in Aurora.For the retrospective study, researchers looked at the cases of 56 children with acute flaccid myelitis in 2015-2016 from 12 medical centers across the country. The children ranged in age from 2-1/2 to 9 years old.The 28 children who received more than one dose of fluoxetine were compared to the 26 children who did not receive the drug and two who had only one dose and were considered part of the untreated group. The children’s muscle strength in their arms and legs was recorded to determine whether the drug was effective.At their first exams, there was no difference between the two groups in muscle strength. But by the end of the study an average of seven months later, the children who had taken the drug had lower strength scores than the children who did not receive treatment. After adjusting for factors that could affect the results, such as age, sex, other treatments the children received and their strength level at the first exam, the researchers found that on a scale of 0 to 20 that grades muscle strength throughout all four limbs, the strength scores of children who received the drug worsened by 0.2, while the scores of those who did not receive the drug improved by 2.5.Related StoriesNumber of fully-immunized Australian kids hits record highUsing Light Scattering to Characterize Protein-Nucleic Acid InteractionsNovel vaccine against bee sting allergy successfully testedThe researchers also looked at the strength score of the weakest limb in each child and found the difference in this score from initial examination to latest follow-up was worse for children who received the drug than those who did not.The drug was well-tolerated by the children, with the number of side effects similar between those receiving the drug and those who did not.A total of 91 percent of the children were sick before developing acute flaccid myelitis, with 71 percent having fever and 73 percent having respiratory symptoms. Weakness started an average of 8.5 days after the start of the illness.More than 40 percent of the children had an enterovirus in their system, with 36 percent having EV-D68. A total of 57 percent of those who received the drug had EV-D68, compared to 14 percent of those who did not receive the drug.Messacar noted that the study has several inherent limitations in that it was looking back in time, patients were not chosen at random to receive the treatment or not and doctors and patients and their families were aware that they were receiving the drug. In addition, the small number of patients may make it difficult to draw definite conclusions.Source: https://www.aan.com/PressRoom/Home/PressRelease/2678last_img read more

Living transplant donors also need longterm monitoring to prevent adverse events

first_imgReviewed by James Ives, M.Psych. (Editor)Apr 11 2019While organ transplant recipients receive continual care as the end-stage treatment to their condition, attention also should be given to living donors, who can suffer from hypertension, diabetes and other disorders after donation, according to a study by researchers at UC San Francisco.As reported online April 12, 2019, in JAMA Network Open, by aggregating data from publicly available clinical studies, the researchers found that nearly one in seven kidney donors experienced a potentially adverse event that may be related to their donation.”Our findings are significant for the transplant community,” said co-senior author Minnie Sarwal, MD, PhD, professor of surgery, medicine and pediatrics at UCSF. “We want to encourage donation, yet making the process more transparent for outcomes and safer by improved monitoring for donors, which does not exist long term, also appears to be of critical importance.”Solid organ transplant is the preferred treatment for most end-stage organ diseases, and about 6,000 adults in the United States and 30,000 worldwide are living donors annually. However, some living kidney donors develop postoperative kidney failure and enter the organ donation system as potential recipients on the transplant waiting list, and this group also is at increased long-term risk for cardiovascular and end-stage renal disease, as well as all-cause mortality, compared to matched nondonors eligible to donate.In the new paper, Sarwal and her colleagues analyzed 20 clinical transplant studies compiled between 1963 and 2016 and housed in ImmPort, a clinical and molecular data repository hosted by the National Institute of Allergy and Infectious Diseases, to review 9,558 donors, referring to their final data set as “ImmTransplant.” To validate the study’s accuracy, they used data collected from 1987 to 2016 and stored in the U.S. national transplant registry maintained by the Organ Procurement and Transplantation Network administered by the United Network for Organ Sharing.While no recorded events occurred in 85.3 percent of donors, the most common adverse events were hypertension (806 cases, 8.4 percent), diabetes (190, 2 percent), proteinuria (171, 1.8 percent) and lack of bowel movements post-surgery (147, 1.5 percent). Relatively few events (269) occurred in the first two years after donation, and of the 1,746 events occurring from two to 40 years after, 1,575 cases (90.2 percent) were nonsurgical.Related StoriesNovel vaccine against bee sting allergy successfully testedCancer incidence among children and young adults with congenital heart diseaseImplanted device uses microcurrent to exercise heart muscle in cardiomyopathy patientsU.S. transplant programs are required to follow up with donors for only two years after transplant.Further, the researchers found that living kidney donors can experience renal or cardiovascular issues that increase their likelihood of renal failure without first experiencing intermediate events. Complications or conditions soon after donation also may not be predictive of long-term renal function or vice versa. As such, long-term systematic renal monitoring and routine regular checkups for living kidney donors is recommended.Sarwal said this study supplements ongoing research while a nationwide registry is being established to improve the recruitment, awareness, education and long-term health management of potential living donors, per an initiative launched after a June 2016 White House organ donation and transplant summit.Demographic characteristics from the study also can provide insights into donation patterns and potential strategies to better inform living donors, said Sarwal, treasurer of The Transplantation Society, an organization whose goal is to provide global leadership in transplantation.For example, a spike was found in living kidney donations among U.S. women whose age was in the childbearing range (age 25). As kidney donation increases the risk of hypertension and preeclampsia in pregnancies, living donors in this age range should be better informed and counseled.”We hope these findings supplement well-informed discourse for living organ donation among potential donors, recipients, clinicians, researchers and the public,” said lead author Jieming Chen, PhD, a former postdoctoral researcher at UCSF now with Genentech. “We’ve curated the transplant datasets in ImmPort as an initial proof of concept of its utility and applications so that the collection, curation and secondary analyses of other publicly available transplant data can be built on.” Source:https://www.ucsf.edu/last_img read more