Raiders inactives: Rodney Hudson, Trent Brown to play vs. Chargers

first_imgALAMEDA — The Raiders will have their offensive line intact Thursday night against the Los Angeles Chargers, as both center Rodney Hudson and right tackle Trent Brown are active.The projected starting line of left tackle Kolton Miller, left guard Richie Incognito, Hudson, right guard Gabe Jackson and Brown have been together for only 10 snaps this season against the Houston Texans.Hudson missed last week’s 31-24 win over the Detroit Lions with an ankle injury, while Brown left after seven …last_img

Net-Zero Homes, Part 3

first_imgIn Part 3 of this episode, the net zero conversation winds down as Phil and I talk about the “cost trade-off” game in which the homeowners will likely engage. We also have a bit of a disagreement as to how much the clients need to know about the energy-saving details being incorporated into their homes. (Good stuff.)The Highlights:How to make net zero cost-effective. It’s a trade-off between mechanicals and envelope design.Photovoltaics: Expensive, but right now you get 30% off. Why aren’t we all putting PV on our homes?Again, remember 10, 20, 40, 60: It’s a good rule of thumb to get you close to what you need. (R-10 basement slab, R-20 foundation walls, R-40 exterior walls, R-60 roof/ceiling assembly)Net-zero ready counts! It’s relatively easy to add PV later; not so with insulation and window upgrades.Point, counterpoint! Phil and I have different ideas about how much the clients “need to know” about the details of energy efficiency in their homes.Lessons learned: Integrated design. Have well-established goals. Pay attention to the Germans and Canadians. Don’t be afraid of transparency—seek and share advice. Chris: No.Phil: Do they assume the building we design is going to leak?Chris: It is not going to leak.Phil: Do they assume the building is going to use a lot of energy?Chris: No.Phil: Exactly. Why do we need to tell them? They come to us for that. Why do we need to have a conversation about your wall section? No, we don’t have to have that. We just have to know we did the best job internally. Why do the owners have to know it unless it’s going to cost them more money?Chris: The second I’ve got you pegged, you always surprise me, Phil.Phil: We don’t need to talk about wall sections and detailing and which way the wall dries out and how much insulation. We only need to talk about quality, comfort, durability and security — and that it’s not going to cost them any more. I am proposing something radical: Don’t talk to your client about how much more insulation you’re going to put in and don’t try to sell them on it. It’s not an issue anymore.Chris: You make the assumption that the client wants an energy-efficient house, is that what you’re saying?Phil: Well, you make the assumption that the client wants a high quality house, right? Can you give them high quality and comfort that doesn’t cost more? As long as the client wants that, we’re not going to talk about anything else.Chris: You’ve blown my mind, Phil. But there’s a part of me that wants to say, Wait, I want to show the client what I’m working on.Phil: That’s the geeky ego. I have a hard time resisting that.Chris: I know! Look at this! Look at the gorgeous detail, Mr. Client! Look at what I’ve done for you!Phil: Look at how smart I am! But really, we have bigger goals now. In ten years we’re not going to be talking about it. We don’t tell clients we’re using 2×6 walls or batt insulation; they don’t give a damn. Ten years from now, they’re not going to give a damn about double-stud walls or 4 inches of rigid foam. Most don’t give a damn now.Chris: And the name of my business won’t be Green Design Studio, because Green will be meaningless.Phil: Unless you change your last name to Green.Chris: Which maybe I’ll do.Phil: OK, let’s talk about the lessons we’ve learned doing net-zero homes. I know I sounded cavalier about it, but we’re here to push a little bit.Chris: It could be the drink. It makes you sound tough.Phil: I wish it were that simple.Chris: What are the lessons you’ve learned?Phil: There’s been a lot of talk about the integrated design process — getting the builder on board early.Chris: You and I do that all the time. When’s the last time you’ve taken a house out to bid traditionally?Phil: Not.Chris: Me neither. It just doesn’t happen anymore.Phil: You just have to advocate to your client that’s not the smartest way to go.Chris: We have to do a podcast on the construction contract of delivering your green house.Phil: We have some good builders around here who do that on a regular basis.Chris: You have a design plan, elevations, wall sections, that’s it — and the rest is all assumptions. You invite some builders in to talk about it. They become part of the team — not only for the price and cost, but also for some of the responsibilities of delivering this. You’re not going to hit an ach50 of 0.6, or 1 even, without the builder being fully on board for delivering a tight house. If they just want to do business as usual and get this thing done and go home…Phil: Or not lose money and say to the client, “I could save you a lot of money by not doing this. Trust me, it’ll be close enough, don’t worry about it.”Chris: “I’ve been building like this for years. It’s how my dad taught me.”Phil: So, you’ll get yourself in trouble without an integrated design process.Chris: And we want good numbers, right? Integrated design process — and you have goals in terms of … You want net zero and you have the builder and client at the table, and you say, “Here’s where we need to be, folks. We want a HERS score of about 40. We want our Btu per square foot to be…” What?Phil: I say 20,000.Chris: Btu per square foot per year.Phil: A Passivhaus is under 5,000 Btu, but we don’t have to get that low.Chris: Cause we’re going to supplement with PV. Or something.Phil: Down to 20,000, but if we get down lower that’s great.Chris: And your ach50—you want to try for 1.0. You get a pat on the back and the stamp of approval from Green Architects’ Lounge that you designed and built a nice house.Phil: But you can get a 0.6. You, builder right there, you can’t do it? I’m telling you, you can, if you’re good enough.Chris: If you’re man enough.Phil: But the math is hard.Chris: You know what’s working for you? The sun. It rises and sets each day and gives you free light and heat. You’ve got to work with that, right?Phil: Right. You’ve got to use it. It’s free. Pay attention to the Canadians and the Germans.Chris: What’s up with them? They’re culturally opposite, don’t you think? But they come from northern climes, and we can get really great glazing from the Canadians. And from the Germans.Phil: Canadians do it a little cheaper. Germans do it a little better. Martin Holladay has a great slide from his superinsulation slide show: It’s not the Canadians and the Germans; it’s the Canadians and the hippies. Don’t be afraid of transparency. Give and receive, learn, read, research; don’t do this yourself.Chris: And balance. You can overglaze and you can underglaze. We gravitate toward those great light spaces, but dude, be careful. It’s a delicate dance. Use those energy models. What else, Phil?Phil: Have clear goals at the outset. Know what you’re going for. Yes, net-zero is one.Chris: But everything it entails.Phil: The clear goals at the outset, when you sit down with your client, are to say we want to be net zero. Are you on board? Here’s what we need to do. Not to say, “Well, we did a pretty good house. Do you want to take it to net zero?” Too late. The bird has flown.Chris: I think we’re wrapping up this thing.Phil: Do you have a six-digit idea, Chris?Chris: You know I do. The minisplit is all the rage, right? I can’t be the first one to think of this. In cold climates, what’s the problem with heat pumps? The colder it gets, the less efficient they are — which is the most annoying thing about them, because you need them the most when it’s cold.I just went to a great heat-pump seminar. The truth is most of your heating and cooling is in the more moderate seasons. Rarely here in Maine does it stay below zero. At that point, is my COP 1 because the resistance is on?Here’s my point: Can we make a directional minisplit unit? By that I mean, instead of having a unit that sits outside the building shedding cold and pumping heat into your house, can’t we make it directional and put most of it in a passive solar box? You’d have a tiny passive solar building that the compressor sits in, so when it’s 1 degree outside and sunny, it’s probably 30 in that thing, where its efficiency is much better and it’s throwing heat outside the box. I’m talking about passive solar heating of the unit to keep it warm.Phil: It’s clever, but how much does it cost to build a building for the unit?Chris: Go to Home Depot, 85 bucks. But I’m saying, “Hey manufacturers, hey Japanese!”Phil: The minisplits need some ventilation around them, though, right?Chris: They need lots of ventilation.Phil: So you’d need an open box, right?Chris: Yeah, but blow it out all to one side, like my laptop ventilates.Phil: Did you just tell me to blow it out one side, Chris?Chris: Yeah, blow it out to one side! Do you have a six-digit idea, hotshot?Phil: I don’t have a six-digit idea; I have a six-digit idea in hot pursuit.Chris: Ooo, now I’m interested! Is this a new segment?Phil: We need hot pursuit music from “C.H.I.P.S.” So, you mentioned cellulose SIPs, right?Chris: Yeah, a long time ago. Why not?Phil: And we talked about doing a deep-energy retrofit. Wouldn’t it be great if there were a deep-energy retrofit system that included the windows? Well, we’re working on a deep-energy retrofit project and we’re doing some brainstorming around those ideas, so stay tuned. We’re working on a SIPS panel with Paradigm triple-glazed windows pre-installed. I think we could be in and out in three days.Chris: No way! That’s the holy grail! Perhaps. Except for the vinyl. Paradigm, I love you, but…Phil: It’s affordable, though. If we could do this affordably, we could change a lot of houses. Stay tuned.[The guys end with a friendly discussion about Conor Oberst, his band Bright Eyes, hipsters, Omaha, and Phil as the coolest guy in town. They listen to the Bright Eyes song “Shell Games.”] RELATED ARTICLES PODCAST: Net-Zero Homes, Part 1PODCAST: Net-Zero Homes, Part 2PODCAST: Passivhaus, Part 1 Net-Zero Energy versus Passivhaus Do Grid-Tied Photovoltaic Systems Really Have an Advantage?Testing… Testing… Homes as Net-Zero LaboratoriesNet-Zero Modular Homes Head for Peaks Island, MainePinpointing Leaks With a Fog MachineThinking About Net Zero Energycenter_img We finish with a couple of “six-digit ideas”—ideas that we think would earn a sum that has at least six digits if someone ran with them and developed them. Mine is basically improving the efficiency of a heat pump by housing it in a “passive solar shroud.” Phil’s is a six-digit idea “in hot pursuit”; he reports that a builder with whom he is working is running with one of our previous ideas, the “cellulose SIP.” Then, of course, Phil takes us out with music he thinks you should be listening to: “Shell Games” by Bright Eyes.Also, don’t forget to go back to Part 2 where you can download Phil’s handy spreadsheet, which his office uses to help run the options and find that “sweet spot” for net-zero homes (it’s a living document that has recently been updated).Thanks for tuning in everyone. Cheers.TRANSCRIPTPhil Kaplan: Where were we, Chris? We’re going to talk about how to make net-zero cost-effective.Chris Briley: That’s right. Would you mind if I just throw that question right back at you? Because you did — you’ve done — a net-zero. Isn’t that the biggest hurdle? Net-zero sounds great — you talked a great game in the last episode — but how is it cost-effective; how is it smart?Phil: Well, the key is to make it cost-neutral, because then it’s a home-run and there’s no reason not to be doing this.Chris: Given the choice between two things that are equal, but one is greener…Phil: Or more durable…Chris: Or energy-efficient…Phil: Right, then there’s no reason to do the first one. If we can reduce the mechanicals, improve the envelope, do everything right that we talked about previously — daylighting, solar gain to reduce the electric load, and natural ventilation — to get rid of the furnace, to get rid of fossil fuels, we can get a single point source of heat, like a wood stove or an air-source heat pump with a wood stove backup.The furnace is gone, we have solar hot water, then we reduce our need for renewables. We use our cost optimization spreadsheet, which you can download. We’re spending $30,000 or so for all the PV we need and solar hot water, not $160,000, because we’ve done the first two things right. The costs are offset. You take that money you saved and put it in the envelope. The argument also is that PV is not that cheap now. But that’s OK, because net-zero-ready also counts. When the PV gets real cheap and your state has proper kickbacks, then you’re going to add that PV; just prep for it.Chris: But right now, with the federal tax credit, you’re getting 30 percent off that thing, which is huge.Phil: That begs the question: Why not do this in every home, Chris? I don’t know!Chris: I don’t know either. I don’t have it in my house, but my roof is terrible for it.Phil: So keep going! The truth is we do know.Chris: Because it’s expensive!Phil: I don’t know that it’s expensive. There are cost offsets.Chris: Phil, can I borrow $20,000? No…. because you don’t have $20,000.Phil: Yes, Chris, you can! I was going to spend this $20,000 on a furnace, but I don’t need a furnace. Take this $20,000.Chris: Well done. Touché.Phil: I honestly think it’s about that trade-off. No toe-dipping — you have to jump right in. You need to do all this to a certain point, where the need for a mechanical system drops away and you can take that money and put it in the envelope.Chris: If you’re doing net-zero and your client is on board, it’s like jumping the Grand Canyon. You can’t do it in two steps. You have to prepare, you have to talk, you have to be deliberate in everything you do before taking one gorgeous jump across this canyon. There’s no halfway on this.Phil: But there is a learning curve. Why not do this in every home? Well, people are still trying to figure it out. We can say 10, 20, 40, 60 — most architects don’t know what that means, and most builders don’t know what that means. They’ll laugh. Even when we draw it, if you’ve never built one before, it’s tricky. We need to figure out how to get things this airtight, and it’s a risk. It’s scary advocating not to have a mechanical system in your house.Chris: Let’s say I’m a skeptic. There’s no way net-zero is cost-effective. Give me $12,000, I’ll put an oil boiler in my house, and boom, I’m done. None of this $40,000 PV. How is this cost-effective, Mr. Smarty-Pants Architect?Phil: You don’t need the oil boiler. You just don’t need it.Chris: OK. You’ll save $12,000 on the boiler because you’re not buying it, but you’ll spend $40,000 on the PV — but you’re also not going to spend $4,000 every year; you’ll spend $400 every year. In fact, essentially you’re spending nothing after you’re done. Right? Once you’re net-zero, your utility bills are zero. You’re living there for free. It’s kind of like if you took the cost of your house for 30 years, how much does it cost to live there for 30 years? With buildings in general, the construction cost represents 11% of the cost of the building. Tiny. Tiny. Buildings last a long time, and the cost of everything goes up. The construction is a fraction. But that’s what you’re getting a loan for — the construction cost. It’s what you’re investing in — this number. But you’re living in this house and it’s consuming and the numbers add up — 5 grand every year, over and over and over again. It’s a lot of money.Phil: It is, if you start adding those numbers up. But right now, you’re going to have trouble financing that PV. You just have to have faith that the cost of PV will come down. Again, net-zero ready counts.Chris: It will. PV will come down, oil will go up.Phil: I have a rhetorical question. Is a commitment from the owner necessary?Chris. Oh my gosh, yes.Phil: Point, counterpoint. Chris Briley says yes! Phil Kaplan says, “Well, I don’t know about that…”Chris: No way!Phil: If it’s cost-neutral, and if the owner doesn’t care one way or the other, why even tell him? Chris, do we walk owners through the flashing details? Phil and I would love to hear from you. If you have a great idea for an upcoming topic, want to leave general feedback, or want to share your favorite cocktail recipe, you can e-mail us at GALounge@greenbuildingadvisor.com. If you’d like to complain about our tangential ramblings, fragment sentences, or our general irreverence, you can email us at Complaints@StraightToTheTrashBin.com. Subscribe to Green Architects’ Lounge on iTunes—you’ll never miss a show, and it’s free!RELATED MULTIMEDIAlast_img read more

Interview: Keeping Score with Film and Television Composer Nathan Barr

first_imgWe sat down with Nathan Barr for a conversation about composing sound tracks for films — and how a composer fits into the overall production crew.Cover image via Nathan Barr.Nathan Barr, who has brought the chills to Eli Roth’s Cabin Fever, the sultry to Alan Ball’s True Blood, and the intrigue to FX’s The Americans, gives us insight into all things composing.Image via IMDB.PremiumBeat: When I look at your credits and abilities, it’s easy to be impressed. Then I remember that I gave you your first opportunity to show it, and I feel like a freaking genius for recognizing your awesomeness! Of course, at the time, you were assisting Hans Zimmer. How influential was that experience for you as an artist?Nathan Barr: Yes Traveling Companion was my first film ever! I remember coming up with the main theme in Hans’s writing room, which he generously let me use when he wasn’t working. I remember you and your editor David coming over, and feeling pretty awesome being able to preview some ideas for you in his amazing room, sitting at his desk. He was also very generous in letting me join him in various meetings when it was appropriate. I got a front row seat peering into the life of one of the most successful film composers in history, and I still vividly remember how exciting that time was.  When I started developing my own career after leaving Hans, I had to find my own way of writing that was comfortable for me. My experience with Hans taught me a lot about how I would differentiate my compositional process from his. For example, his writing space at that time was not set up to record live instruments. It was packed full of noisy samplers and synths that made recording anything in the room impossible. Also, whereas he worked almost exclusively “in the box,” I wanted to have microphones up and readily available so I could experiment with my growing collection of musical instruments.Nathan Barr Studio. (Photo by Nathan Barr.)PB: How important is it to you to get along with the director, and do you like more freedom or more direction when you are creating a score?NB: While I do know of examples where conflict between a director and a composer has yielded great musical results, it makes the whole process unpleasant and tortuous. Some of the work I am proudest of has been the product of supportive directors and show runners who trusted me to explore without too much interference. While these individuals look at the process of creating the score as collaborative, it’s also important to them to let others express themselves — and that’s empowering.True Blood. Image via HBO.PB:  If there is one word that I could use confidently to describe you, it would be “versatile,” and I would use that word in several different contexts. Artistically, you move flawlessly between genres (romance, horror, drama, adventure, comedy) and media (features, television, shorts, docs, webisodes), and skillfully, you play so many different instruments. Do you view a story and the tools you use to score it as varied colors on a single palette or do you approach each project very differently?NB: I definitely try to view each project through a new musical lens. While I may begin the scoring process for a new project from the finishing point of the previous project, hopefully I end up in a new place I haven’t visited before when all is said and done. And I do love the versatility of what I do as a film/TV composer. Jumping from a western to a horror film to an indie drama is a thrill, and it keeps the process fresh and exciting.The House with a Clock in Its Wall. (Image via Universal Pictures.)PB: Clearly, you must work very closely with the director and producers when you are scoring a film, but what other departments and crew positions are extremely helpful or important for your process? For example, cinematographers work closely with directors, but often the production and costume design team could heavily influence their lighting and setups.NB: Honestly, one of the most important collaborations for a composer beyond the director is the picture editor. A well-cut film is infinitely easier to score than something that has not been put together effectively. Great picture editors cut every scene with a natural rhythm or tempo in mind, which directly impacts the composer’s music.  Two other important crew positions that composers interface with are the music editor and the post-production supervisor. The former is there to protect the score during the dub, help shape the score, and keep track of spotting notes and cues sheets — and the latter is there to make sure schedules align.The Americans. (Image via 20th Television.)PB: I understand you recently purchased and restored the Wurlitzer that resided on the 20th Century Fox scoring stage from 1928 until 1994. You collect and play very traditional and unusual instruments. How much of the history of cinema and world culture influences your work?NB: The history of cinema is very important and influential to me. When I first got into this business 20 years ago, I spent my first couple years educating myself by devouring films from great directors all over the world and in all time periods. Whether it was Truffaut, Hitchcock, Kubrick, or Tartovsky, I watched and watched and listened and soaked everything up. This all continues to influence my work today. For example, David Shire’s scores to Coppola’s film The Conversation and The Taking of Pelham 123 were starting points for me with my score for The Americans. Buying the Wurlitzer Theater Organ that was built for the scoring stage at Fox in 1928 has already impacted me as far as the current projects I am working on. I believe that instrument and its place in film history will profoundly affect my creative output in the coming years.Image courtesy of Nathan Barr.PB: Finally, as someone who is incredibly curious and creative, what new technology have you been using in your composing, and what new toys on the horizon that you’ve heard about (if any) are you most excited about incorporating in your work?NB: The Wurlitzer is the latest toy/tool I am thrilled to be exploring. I am also having a friend build an unusual instrument based on a pipe organ that will allow me to experiment with organ pipes in a way that would not be possible in the context of an installed organ. It is called the “Herman-Taylor High-Pressure Stout-O-Phone.” It’s a collaboration between several folks in the organ business, including the legendary Edward Millington Stout III and Dick Taylor, who are among the best in the business. New creations like this get me so excited about what I do.Looking for more film industry interviews? Check these out.Interview: The Film Collaborative on Filmmaking Rights and DistributionInterview: The Editor of “This is America” on Building the Iconic VideoSet Your Film Right: On Location with Robert FoulkesAn Interview with Andrew Shulkind, DP of Netflix Original film The RitualExclusive: Designing Wakanda and the Amazing Sets of Black Pantherlast_img read more

a day ago​Dele Alli insists Spurs players behind Pochettino

first_imgAbout the authorFreddie TaylorShare the loveHave your say ​Dele Alli insists Spurs players behind Pochettinoby Freddie Taylora day agoSend to a friendShare the loveTottenham star Dele Alli believes that everyone at the club is firmly behind their manager Mauricio Pochettino.Spurs are struggling for confidence and form, especially in the Premier League.It has seen them slip in the top four race and prompted talks about Pochettino’s future at the club. But Alli insists every one of Spurs’ players is behind the Argentine coach.He told reporters: “Yeah, 1,000 per cent [players are behind Pochettino].”A lot of us would not be where we are now if it was not for him. All we can do is thank him.”We have always trusted him 100 per cent and we are going to keep doing that. We are a team.”When things are not going our way, it is easy for people to try and get at the manager but we need to look at ourselves as players.”We’re doing that and we are going to keep working hard.” last_img read more

Vine: R.J. Hunter’s Cold-Blooded Three-Pointer Stunned No. 3 Seed Baylor

first_imgR.J. Hunter hits huge three vs. Baylor.Georgia State, the No. 14 seed in the West Region, just ended the game on a 13-0 run to shock No. 3 seed Baylor, 57-56. Georgia State guard R.J. Hunter, the son of GSU head coach Ron Hunter, hit the game-winning three-pointer from way downtown with 2.8 seconds remaining.Hunter struggled much of the day, scoring just two points in the first half. His dad coached the whole game in a rolling stool after tearing his left achilles tendon celebrating the team’s Sun Belt Conference championship last week.This is what happened to Ron Hunter when R.J. made his game-winner. March Madness is amazing.last_img

Large LNGFueled Crude Oil Tanker to Cross NSR for 1st Time

first_imgRelated:World’s 1st LNG-Powered Aframax Completes Maiden VoyageShell’s Cardissa Carries Out Its 1st LNG Ship-to-Ship BunkeringSovcomflot Reports Significant CO2 Cuts from New LNG-Powered Tankers,Related:World’s 1st LNG-Powered Aframax Completes Maiden VoyageShell’s Cardissa Carries Out Its 1st LNG Ship-to-Ship BunkeringSovcomflot Reports Significant CO2 Cuts from New LNG-Powered Tankers zoomIllustration. Image Courtesy: Sovcomflot/Navigate PR Korolev Prospect, Sovcomflot’s LNG-fueled Aframax crude oil tanker, began a transit of the Northern Sea Route (NSR) on August 26, 2019.The 123,492 cbm vessel will become the first such large-capacity crude oil tanker to travel the entire length of the NSR using only clean-burning LNG fuel, Sovcomflot said.The 113,200 dwt tanker is carrying a cargo of crude oil from the Russian port of Murmansk to China.The journey along the NSR, from Cape Zhelaniya to Cape Dezhnev, will take about eight days, with vessel moving at the expected average speed of 12 knots, according to the Russian shipping company.While transiting from the Laptev Sea to the East Siberian Sea, the vessel will follow the ‘Tikhonov’ deep-water route that lies north of the New Siberian Islands, which was first opened for commercial shipping in 2011 by SCF’s tanker Vladimir Tikhonov.Compared with standard marine fuels, vessels using LNG fuel achieve a significant reduction in vessel emissions whilst also improving the ship’s energy efficiency.Today, Sovcomflot has six LNG-fueled crude oil tankers in operation, including Korolev Prospect, and five more under construction.Delivered by Korean shipbuilder Hyundai Samho Heavy Industries in February 2019, Korolev Prospect features a length of 250 meters, a breadth of 44 meters, and an ice class of 1A hull.Sovcomflot’s fleet currently includes 146 vessels with a total deadweight of over 12.8 million tons. More than 80 vessels have an ice class.last_img read more

Study uncovers new biomarker for personalized cancer treatments

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Apr 16 2019Cancer cells are characterized by the ability to evade apoptosis, a type of programmed cell death that allows the organism to remove damaged cells. Many studies devoted to new chemotherapy treatments aim to induce apoptosis and thus remove cancer cells or reduce the size of the tumor. Scientists at the Institute for Research in Biomedicine (IRB Barcelona) have demonstrated that the protein TP53INP2 plays an important role in the induction of cell death. This finding could be relevant in the treatment of certain types of cancer.”We observed that when cells have high levels of TP53INP2, apoptosis is accelerated when specific receptors on the cell membrane are activated. In contrast, the cells that did not express this protein were more resistant to apoptosis,” comments Antonio Zorzano, head of the Complex Metabolic Disease and Mitochondria Lab at IRB Barcelona.Related StoriesBacteria in the birth canal linked to lower risk of ovarian cancerSugary drinks linked to cancer finds studyStudy reveals link between inflammatory diet and colorectal cancer riskPublished in EMBO Journal, this study describes how this protein increases the efficacy of certain chemotherapy treatments, such as TRAIL. “We demonstrate that TP53INP2 makes cancer cells more sensitive to death signals, including TRAIL,” explains Saška Ivanova, postdoctoral fellow at IRB Barcelona and first author of the study.TRAIL holds great promise for the treatment of cancer because it can selectively induce the death of cancer cells. Since its discovery in 1995, many clinical assays have been devoted to this drug. However, not all patients with cancer respond to this treatment. Researchers at IRB Barcelona have confirmed the relation between high levels of TP53INP2 and an enhanced response of liver and breast cancer cells to TRAIL.One of the issues regarding TRAIL is the need to identify patients likely to respond to this treatment, as TRAIL can enhance tumor progression in some types of cancer. “We propose the protein TP53INP2 as a potential marker to identify patients that could benefit from treatment with TRAIL,” explains Zorzano, full professor at the University of Barcelona and CIBERDEM researcher.Personalized medicine, an approach that allows treatment to be adapted to the characteristics of each patient, emerges as one of the health care strategies with most potential. Knowledge of the type of cancer and selection of the most efficient treatment in each case will increase patient survival. However, biomarkers are needed. In this regard, this study offers a new approach to support physicians in the selection of personalized treatments.”We are now extending the study to other types of cancer, such as lung cancer, to confirm whether TP53INP2 also improves the response to treatment with TRAIL,” adds Ivanova. Source:https://www.irbbarcelona.org/en/news/researchers-identify-a-new-biomarker-for-personalised-treatments-against-cancerlast_img read more

Autonomous vehicles could shape the future of urban tourism

first_img Why driverless vehicles should not be given unchecked access to our cities Provided by University of Surrey More information: Autonomous vehicles and the future of urban tourism. www.academia.edu/37663136/Auto … ure_of_urban_tourism Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Credit: CC0 Public Domain In the first study of its kind, published in the Annals of Tourism Research, academics from the University of Surrey and the University of Oxford have examined how Autonomous Vehicles (AVs) may have a substantial impact on the future of urban tourism. When we think of automated vehicles it seems to be a topic that sits firmly in science fiction, from cars with character in The Love Bug (1969) and Knight Rider (1982) to more recent practical representations in Minority Report (2002). However, according to the new research by Professor Scott Cohen (University of Surrey) and Dr. Debbie Hopkins (University of Oxford), AVs may be spotted on our roads as soon 2025 and could lead to far-reaching impacts on urban tourism.The conceptual paper entitled “Autonomous vehicles and the future of urban tourism” imagines the impact of AVs in future urban tourism and focuses on the pros and cons of these impacts with regards to the transformation of urban space, the rise of autonomous taxis, and changes to city sightseeing and hospitality in the urban night.Potential benefits include reduced traffic congestion and emissions, improved foreign car hire processes, reduced parking requirements and cheaper taxi fares. AVs may impact other industries in radical ways too, such as Amsterdam’s Red Light District, which could become operated out of moving AVs, and restaurants and hotels may encounter new competition in the form of AV dining cars and passengers sleeping in their moving vehicles.AVs are also the subject of many concerns. More time spent in cars on longer journeys could facilitate greater urban sprawl and increase car dependency. AVs may reduce demand for train travel, coach tours, public transport and driven taxis—all resulting in future job losses. The potential for terrorism facilitated by AVs also raises genuine security fears.Professor Cohen, Head of Tourism and Transport at Surrey’s School of Hospitality and Tourism Management, said: “This groundbreaking study will benefit urban planners, policy makers and the tourism and hospitality industries, who will face a range of threats and opportunities as AVs begin to reach the mass market in the coming decade.”The visitor economy will be gradually transformed if AVs become fully automated and mainstream, leading to a future where hordes of small AVs could congest urban attractions, hop-on hop-off city bus tours may go out of business altogether, motorways between cities could fill at night with slow-moving AVs carrying sleeping occupants and commercial sex in moving AVs becomes a growing phenomenon.”The paper calls for future work that provides context-specific analyses that may reveal alternative ways of thinking about AVs for urban tourism. Its release coincides this week with the World Travel Market and European Tourism Day on 7 November and acts as a timely reminder of the rising importance and significance of AVs in tourism to industry and policy makers. Citation: Autonomous vehicles could shape the future of urban tourism (2018, November 7) retrieved 17 July 2019 from https://phys.org/news/2018-11-autonomous-vehicles-future-urban-tourism.htmllast_img read more

Tesla shares fall after surprise CFO exit

first_img © 2019 AFP Shares of electric carmaker Tesla Motors were under pressure Thursday following the surprise replacement of the company’s chief financial officer. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further Shares of Tesla declined following the surprise replacement of its chief financial officer.center_img Chief Executive Elon Musk announced the shift in the final moments of an earnings conference call on Wednesday night, saying Deepak Ahuja, 56, would be replaced by Zach Kirkhorn, currently a vice president in finance.Ahuja’s departure follows other executive turnover at the hard-charging Musk’s electric car company.Tesla shares were down 0.4 percent at $307.42 at mid-morning after falling as much as 4.8 percent earlier in the session.A note from JPMorgan Chase highlighted the exit as a key disappointment following Tesla’s mixed results, citing the outgoing executive’s “long automotive industry experience” and 11 years at the company.Ahuja “provided relative stability to the firm’s finance staff that has otherwise seen a great deal of churn,” the JPMorgan note said.A Canaccord Genuity note said Ahuja’s exit was “likely to stir investor concerns around corporate culture of Tesla, which has been a concern in the past.”Kirkhorn, 34, who started at Tesla in 2010 and returned after a stint at Harvard Business School, told analysts the company was in a “strong” financial position.”We have enough cash to continue launching new programs and developing new technologies and we’re able to service upcoming debt obligations with our forecasted cash flows,” he said.Tesla on Wednesday reported fourth-quarter profits of $139.6 million, up from a loss of $675.4 million in the year-ago period.Revenues more than doubled to $7.2 billion, reflecting the ramp-up of the company’s Model 3 sedan.Musk remained upbeat about the company’s prospects and sales, saying that while 2018 was a challenging year, it also was the most successful. Citation: Tesla shares fall after surprise CFO exit (2019, January 31) retrieved 17 July 2019 from https://phys.org/news/2019-01-tesla-fall-cfo-exit.html Tesla shares fall again on doubts about go-private deallast_img read more